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Page 1
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG. Mete O, et al. Endocr Pathol. 2022 Mar;33(1):155-196. doi: 10.1007/s12022-022-09710-8. Epub 2022 Mar 14. Endocr Pathol. 2022. PMID: 35288842 Free PMC article. Review.
The pathological correlates of adrenal cortical proliferations include diffuse adrenal cortical hyperplasia, adrenal cortical nodular disease, adrenal cortical adenomas and adrenal cortical carcinomas. ...For this reason, the new WHO classification endorses the nomenclatur …
The pathological correlates of adrenal cortical proliferations include diffuse adrenal cortical hyperplasia, adrenal cortical nodular …
Morphologic and Molecular Characterization of Adrenals and Adrenal Rest Affected by Congenital Adrenal Hyperplasia.
Kolli V, da Cunha IW, Kim S, Iben JR, Mallappa A, Li T, Gaynor A, Coon SL, Quezado MM, Merke DP. Kolli V, et al. Front Endocrinol (Lausanne). 2021 Sep 20;12:730947. doi: 10.3389/fendo.2021.730947. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34616364 Free PMC article.
INTRODUCTION: Adrenocortical hyperplasia and adrenal rest tumor (ART) formation are common in congenital adrenal hyperplasia (CAH). ...CYP11B2 was mostly absent in CAH adrenals and absent in ART. DLK1 was present in CAH adrenal, ART, and also control adrenal …
INTRODUCTION: Adrenocortical hyperplasia and adrenal rest tumor (ART) formation are common in congenital adrenal hyperplasia ( …
Update on the Genetics of Primary Aldosteronism and Aldosterone-Producing Adenomas.
Pitsava G, Faucz FR, Stratakis CA, Hannah-Shmouni F. Pitsava G, et al. Curr Cardiol Rep. 2022 Sep;24(9):1189-1195. doi: 10.1007/s11886-022-01735-z. Epub 2022 Jul 16. Curr Cardiol Rep. 2022. PMID: 35841527 Free PMC article. Review.
The two most common forms arise from bilateral adrenocortical hyperplasia (BAH) and aldosterone-producing adenoma (APA). We discuss recent discoveries in the genetics of PA. ...Some of these genes are found mutated in the germline state (CYP11B2, CLCN2, KCNJ5, CACNA …
The two most common forms arise from bilateral adrenocortical hyperplasia (BAH) and aldosterone-producing adenoma (APA). We discuss r …
Unequal crossing over between CYP11B2 and CYP11B1 causes 11 beta -hydroxylase deficiency in a consanguineous family.
Xiong Y, Zeng Z, Liang T, Yang P, Lu Q, Yang J, Zhang J, Fang W, Luo P, Hu Y, Zhang M, Zhou D. Xiong Y, et al. J Steroid Biochem Mol Biol. 2023 Oct;233:106375. doi: 10.1016/j.jsbmb.2023.106375. Epub 2023 Aug 11. J Steroid Biochem Mol Biol. 2023. PMID: 37572761
Cytochrome P450 (CYP) family CYP11B2/CYP11B1 chimeric genes have been shown to arise from unequal crossing over of the genes encoding aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) during meiosis. ...Here,two patients with pseudoprecocious pu …
Cytochrome P450 (CYP) family CYP11B2/CYP11B1 chimeric genes have been shown to arise from unequal crossing over of the genes e …
Exploration of KCNJ5 Somatic Mutation and CYP11B1/CYP11B2 Staining in Multiple Nodules in Primary Aldosteronism.
Xie J, Zhang C, Wang X, Jiang Y, Wu L, Ye L, Wang X, Xie W, Xu H, Wang W. Xie J, et al. Front Med (Lausanne). 2022 Apr 12;9:823065. doi: 10.3389/fmed.2022.823065. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35492351 Free PMC article.
We assessed somatic KCNJ5 mutations, immunohistochemistry for aldosterone synthase (CYP11B2)/cortisol synthase (CYP11B1), and histological cellular composition of nodules together with adjacent adrenal cortical statements. ...Countable nodules could be considered as multip …
We assessed somatic KCNJ5 mutations, immunohistochemistry for aldosterone synthase (CYP11B2)/cortisol synthase (CYP11B1), and histolo …
Immunohistochemistry of the adrenal in primary aldosteronism.
Gomez-Sanchez CE, Gomez-Sanchez EP. Gomez-Sanchez CE, et al. Curr Opin Endocrinol Diabetes Obes. 2016 Jun;23(3):242-8. doi: 10.1097/MED.0000000000000248. Curr Opin Endocrinol Diabetes Obes. 2016. PMID: 27119751 Free PMC article. Review.
Cells expressing CYP11B2 may be scattered and/or in clusters throughout the normal adrenal zona glomerulosa. APA differ widely in the number of cells expressing CYP11B2; some did not express it at all, but were surrounded by cells, some in clusters or micronodules, …
Cells expressing CYP11B2 may be scattered and/or in clusters throughout the normal adrenal zona glomerulosa. APA differ widely in the …
Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism.
Maier P, Heinze B, Gabor S, Reese S, Hahner S, Schirbel A. Maier P, et al. Bioorg Med Chem Lett. 2023 Nov 15;96:129501. doi: 10.1016/j.bmcl.2023.129501. Epub 2023 Oct 5. Bioorg Med Chem Lett. 2023. PMID: 37804995 Free article.
It therefore represents an ideal target for molecular imaging, particularly for the differential diagnosis between bilateral hyperplasia and unilateral APA in primary aldosteronism. However, the presence of the cortisol-producing enzyme 11beta-hydroxylase (CYP11B1) in the …
It therefore represents an ideal target for molecular imaging, particularly for the differential diagnosis between bilateral hyperplasia …
Genetic causes of primary aldosteronism.
Seidel E, Schewe J, Scholl UI. Seidel E, et al. Exp Mol Med. 2019 Nov 6;51(11):1-12. doi: 10.1038/s12276-019-0337-9. Exp Mol Med. 2019. PMID: 31695023 Free PMC article. Review.
The most frequent subforms are idiopathic hyperaldosteronism and aldosterone-producing adenoma. Rare causes include unilateral hyperplasia, adrenocortical carcinoma and Mendelian forms (familial hyperaldosteronism). ...The fact that they are associated with somatic mutatio …
The most frequent subforms are idiopathic hyperaldosteronism and aldosterone-producing adenoma. Rare causes include unilateral hyperplasi …
Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CYP11B2.
Enberg U, Volpe C, Höög A, Wedell A, Farnebo LO, Thorén M, Hamberger B. Enberg U, et al. Eur J Endocrinol. 2004 Jul;151(1):73-85. doi: 10.1530/eje.0.1510073. Eur J Endocrinol. 2004. PMID: 15248825
RESULTS: The resected adrenals had the histopathologic diagnosis of adenoma (11), adenoma and/or hyperplasia (15) or hyperplasia (1). CYP11B2 expression (indicating aldosterone production) was found in a dominant adrenal nodule from 22 patients. Fourteen of t …
RESULTS: The resected adrenals had the histopathologic diagnosis of adenoma (11), adenoma and/or hyperplasia (15) or hyperplasia …
Disordered CYP11B2 Expression in Primary Aldosteronism.
Gomez-Sanchez CE, Kuppusamy M, Reincke M, Williams TA. Gomez-Sanchez CE, et al. Horm Metab Res. 2017 Dec;49(12):957-962. doi: 10.1055/s-0043-122238. Epub 2017 Dec 4. Horm Metab Res. 2017. PMID: 29202495 Free article. Review.
PA is mainly caused by unilateral hyperaldosteronism due to an aldosterone-producing adenoma, unilateral hyperplasia with or without micronodules or bilateral zona glomerulosa hyperplasias with or without macro or micronodules. ...Approximately 30% of patients with …
PA is mainly caused by unilateral hyperaldosteronism due to an aldosterone-producing adenoma, unilateral hyperplasia with or without …
157 results